Article
Comorbidity of congenital heart defects and holoprosencephaly is likely genetically driven and gene-specific.
American journal of medical genetics. Part C, Seminars in medical genetics - 1 Mar 2020
Tekendo-Ngongang Cedrik, Owosela Babajide, Muenke Maximilian, Kruszka Paul
Abstract excerpt
Comorbidity of holoprosencephaly (HPE) and congenital heart disease (CHD) in individuals with genetic variants in known HPE-related genes has been recurrently observed. Morphogenesis of the brain and heart from very early stages are regulated by several biological pathways, some of them involved in both heart and brain development as evidenced by genetic studies on model organisms. For instance, downregulation of...
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