Article
The polygenic architecture of left ventricular mass mirrors the clinical epidemiology.
Scientific reports - 5 May 2020
Mosley Jonathan D, Levinson Rebecca T, Farber-Eger Eric, Edwards Todd L, Hellwege Jacklyn N, Hung Adriana M, Giri Ayush, Shuey Megan M, Shaffer Christian M, Shi Mingjian, Brittain Evan L, Chung Wendy K, Kullo Iftikhar J, Arruda-Olson Adelaide M, Jarvik Gail P, Larson Eric B, Crosslin David R, Williams Marc S, Borthwick Ken M, Hakonarson Hakon, Denny Joshua C, Wang Thomas J, Stein Charles M, Roden Dan M, Wells Quinn S
Abstract excerpt
Left ventricular (LV) mass is a prognostic biomarker for incident heart disease and all-cause mortality. Large-scale genome-wide association studies have identified few SNPs associated with LV mass. We hypothesized that a polygenic discovery approach using LV mass measurements made in a clinical population would identify risk factors and diseases associated with adverse LV remodeling. We developed a polygenic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.