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The mitochondrial DNA copy number of cumulus granulosa cells may be related to the maturity of oocyte cytoplasm

1 Apr 2020

Abstract excerpt

STUDY QUESTION: Is the mitochondrial DNA (mtDNA) copy number of cumulus granulosa cells (CGCs) related to the maturation of oocyte cytoplasm? SUMMARY ANSWER: Compared with the mtDNA copy number of CGCs from germinal vesicles (GV), CGCs from Metaphase I (MI) oocytes appear to have a lower mtDNA copy number. WHAT IS KNOWN ALREADY: The growth and development of CGCs and oocyte are synchronised. The interaction...

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PMID: 32358599
DOI: 10.1093/humrep/deaa085

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