Sensitive detection methods are key to identify secondary EGFR c.2369C>T p.(Thr790Met) in non-small cell lung cancer tissue samples.

doi:10.1186/s12885-020-06831-3

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Article

Sensitive detection methods are key to identify secondary EGFR c.2369C>T p.(Thr790Met) in non-small cell lung cancer tissue samples.

BMC cancer - 1 May 2020

Keppens Cleo, Dequeker Elisabeth M C, Rouleau Etienne, 't Hart Nils, Bubendorf Lukas, Dufraing Kelly, Garrec Céline, Guéguen Paul, Lamy Aude, Marchetti Antonio, Pauwels Patrick, Ryska Ales, Tack Véronique, Tornillo Luigi, Van Casteren Kaat, von der Thüsen Jan H, Zwaenepoel Karen, Lissenberg-Witte Birgit, Thunnissen Erik, Schuuring Ed

Abstract excerpt

BACKGROUND: Correct identification of the EGFR c.2369C>T p.(Thr790Met) variant is key to decide on a targeted therapeutic strategy for patients with acquired EGFR TKI resistance in non-small cell lung cancer. The aim of this study was to evaluate the correct detection of this variant in 12 tumor tissue specimens tested by 324 laboratories participating in External Quality Assessment (EQA) schemes. METHODS: Data...

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Identifiers

PMID: 32357863
DOI: 10.1186/s12885-020-06831-3
PMCID: PMC7193365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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