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Olaparib for Metastatic Castration-Resistant Prostate Cancer

28 Apr 2020

Abstract excerpt

BACKGROUND: Multiple loss-of-function alterations in genes that are involved in DNA repair, including homologous recombination repair, are associated with response to poly(adenosine diphosphate-ribose) polymerase (PARP) inhibition in patients with prostate and other cancers. METHODS: ; cohort B (142 patients) had alterations in any of 12 other prespecified genes, prospectively and centrally determined from tumor...

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PMID: 32343890
DOI: 10.1056/nejmoa1911440

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