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Salivary AMY1 Copy Number Variation Modifies Age-Related Type 2 Diabetes Risk

6 Mar 2020

Abstract excerpt

BACKGROUND: Copy number variation (CNV) in the salivary amylase gene (AMY1) modulates salivary α-amylase levels and is associated with postprandial glycemic traits. Whether AMY1-CNV plays a role in age-mediated change in insulin resistance (IR) is uncertain. METHODS: We measured AMY1-CNV using duplex quantitative real-time polymerase chain reaction in two studies, the Boston Puerto Rican Health Study (BPRHS, n =...

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PMID: 32337541
DOI: 10.1093/clinchem/hvaa072

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