Article
Central memory phenotype drives success of checkpoint inhibition in combination with CAR T cells.
Molecular carcinogenesis - 1 Jul 2020
Toews Karin, Grunewald Laura, Schwiebert Silke, Klaus Anika, Winkler Annika, Ali Solin, Zirngibl Felix, Astrahantseff Kathy, Wagner Dimitrios L, Henssen Anton G, Deubzer Hedwig E, Schulte Johannes H, Ochsenreither Sebastian, Eggert Angelika, Künkele Annette
Abstract excerpt
The immunosuppressive microenvironment in solid tumors is thought to form a barrier to the entry and efficacy of cell-based therapies such as chimeric antigen receptor (CAR) T cells. Combining CAR T cell therapy with checkpoint inhibitors has been demonstrated to oppose immune escape mechanisms in solid tumors and augment antitumor efficacy. We evaluated PD-1/PD-L1 signaling capacity and the impact of an...
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