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Article

Electrophoretic α1-globulin for screening of α1-antitrypsin deficient variants.

Clinical chemistry and laboratory medicine - 25 Oct 2020

Scarlata Simone, Santangelo Simona, Ferrarotti Ilaria, Corsico Angelo Guido, Ottaviani Stefania, Finamore Panaiotis, Fontana Davide, Miravitlles Marc, Incalzi Raffaele Antonelli

Abstract excerpt

Background Available screening procedures for the detection of α1-antitrypsin-deficient (AATD) mutations have suboptimal cost-effectiveness ratios. The aim in this study was to evaluate and compare the viability of a composite approach, primarily based on the α1-globulin fraction, in identifying AAT genetic analysis eligible patients against standard screening procedures, based on clinically compatible profiling...

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PMID: 32324154
DOI: 10.1515/cclm-2020-0071

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