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Article

Dysregulation of the Retromer Complex System in Down Syndrome

22 Apr 2020

Abstract excerpt

OBJECTIVE: Most of the patients with Down syndrome (DS) develop Alzheimer's disease (AD) neuropathology by age 40. Although this increased susceptibility to AD in DS is thought to be primarily due to triplication of the amyloid precursor protein located on chromosome 21, the precise molecular mechanisms are not well understood. Recent evidence has implicated defective protein sorting and trafficking secondary to...

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PMID: 32320094
DOI: 10.1002/ana.25752

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