Inhibitory effect of IQ-1S, a selective c-Jun N-terminal kinase (JNK) inhibitor, on phenotypical and cytokine-producing characteristics in human macrophages and T-cells.

doi:10.1016/j.ejphar.2020.173116

Article

Inhibitory effect of IQ-1S, a selective c-Jun N-terminal kinase (JNK) inhibitor, on phenotypical and cytokine-producing characteristics in human macrophages and T-cells.

European journal of pharmacology - 5 Jul 2020

Seledtsov Victor I, Malashchenko Vladimir V, Meniailo Maksim E, Atochin Dmitriy N, Seledtsova Galina V, Schepetkin Igor A

Abstract excerpt

c-Jun N-terminal kinase (JNK) is a critical mitogen activated protein kinase (MAPK) implicated in inflammatory processes, with IQ-1S (11H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt) being a high-affinity JNK inhibitor with pronounced anti-inflammatory properties. Here, we studied direct effects of IQ-1S on phenotypical and cytokine-producing characteristics of activated human monocytes/macrophages and T...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Inhibitory effect of IQ-1S, a selective c-Jun N-terminal kinase (JNK) inhibitor, on phenotypical and cytokine-producing characteristics in human macrophages and T-cells.

Abstract excerpt

Topics

Related research