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Article

Myofibers deficient in connexins 43 and 45 expression protect mice from skeletal muscle and systemic dysfunction promoted by a dysferlin mutation.

Biochimica et biophysica acta. Molecular basis of disease - 1 Aug 2020

Fernández Gabriela, Arias-Bravo Guisselle, Bevilacqua Jorge A, Castillo-Ruiz Mario, Caviedes Pablo, Sáez Juan C, Cea Luis A

Abstract excerpt

Dysferlinopathy is a genetic human disease caused by mutations in the gene that encodes the dysferlin protein (DYSF). Dysferlin is believed to play a relevant role in cell membrane repair. However, in dysferlin-deficient (blAJ) mice (a model of dysferlinopathies) the recovery of the membrane resealing function by means of the expression of a mini-dysferlin does not arrest progressive muscular damage, suggesting...

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Identifiers

PMID: 32305450
DOI: 10.1016/j.bbadis.2020.165800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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