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Article

Brucella ovis mutant in ABC transporter protects against Brucella canis infection in mice and it is safe for dogs.

PloS one - 1 Jan 2020

Eckstein Camila, Mol Juliana P S, Costa Fabíola B, Nunes Philipe P, Lima Pâmela A, Melo Marília M, Carvalho Thaynara P, Santos Daniel O, Silva Monique F, Carvalho Tatiane F, Costa Luciana F, Melo Júnior Otoni A O, Giunchette Rodolfo C, Paixão Tatiane A, Santos Renato L

Abstract excerpt

BACKGROUND/OBJECTIVES: Vaccination is the most important tool for controlling brucellosis, but currently there is no vaccine available for canine brucellosis, which is a zoonotic disease of worldwide distribution caused by Brucella canis. This study aimed to evaluate protection and immune response induced by Brucella ovis ΔabcBA (BoΔabcBA) encapsulated with alginate against the challenge with Brucella canis in...

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PMID: 32298378
DOI: 10.1371/journal.pone.0231893
PMCID: PMC7162469

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