Article
DCHS1 DNA copy number loss associated with pediatric urinary tract infection risk.
Innate immunity - 1 Aug 2020
Qureshi Aslam H, Liang Dong, Canas Jorge, Hooks Jenaya, Arrregui Samuel W, Saxena Vijay, Rooney Robert, Nolan Vikki, Schwaderer Andrew L, Hains David S
Abstract excerpt
Urinary tract infections (UTI), associated with vesicoureteral reflux (VUR), can lead to chronic kidney disease. Genetic alterations in the innate immune defenses contribute to UTI risk. We investigated a novel gene, Dachsous Cadherin-Related 1 (DCHS1), in children with UTI. We determined absolute DNA copy number (CN) of DCHS1 in children with UTI. In this case-control study, we utilized multiple complementary...
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