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Article

Evolution of male pregnancy associated with remodeling of canonical vertebrate immunity in seahorses and pipefishes

13 Apr 2020

Abstract excerpt

A fundamental problem for the evolution of pregnancy, the most specialized form of parental investment among vertebrates, is the rejection of the nonself-embryo. Mammals achieve immunological tolerance by down-regulating both major histocompatibility complex pathways (MHC I and II). Although pregnancy has evolved multiple times independently among vertebrates, knowledge of associated immune system adjustments is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32284407
DOI: 10.1073/pnas.1916251117

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