Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HPV E6 and E7 oncoproteins cooperatively alter the expression of Disc Large 1 polarity protein in epithelial cells

7 Apr 2020

Abstract excerpt

BACKGROUND: Persistent infection with high-risk Human Papillomavirus (HPVs) is associated with the development of cervical cancer. The transforming capacity of these viruses relies on the cooperative action of the E6 and E7 viral oncoproteins. Among the oncogenic activities of E6, the interaction and interference with cell polarity PDZ proteins have been well established. One of the most characterized PDZ targets...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cervical Cancer and HPV Research
Share to Hippo pathway signaling and YAP/TAZ

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32264889
DOI: 10.1186/s12885-020-06778-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HPV E6 and E7 oncoproteins cooperatively alter the expression of Disc Large 1 polarity protein in epithelial cellsPMID 32264889Read ↗

Human papillomaviruses and the specificity of PDZ domain targetingSemantic proximity Read ↗

Human papillomaviruses, cervical cancer and cell polarity.Semantic proximity Read ↗

E6AP-Dependent Degradation of DLG4/PSD95 by High-Risk Human Papillomavirus Type 18 E6 ProteinSemantic proximity Read ↗

Stabilization of HPV16 E6 protein by PDZ proteins, and potential implications for genome maintenanceSemantic proximity Read ↗

A Systematic Analysis of Human Papillomavirus (HPV) E6 PDZ Substrates Identifies MAGI-1 as a Major Target of HPV Type 16 (HPV-16) and HPV-18 Whose Loss Accompanies Disruption of Tight JunctionsSemantic proximity Read ↗

Oncogenic Human Papillomaviruses Activate the Tumor-Associated Lens Epithelial-Derived Growth Factor (LEDGF) GeneSemantic proximity Read ↗

Human papillomavirus (HPV)‐18 E6 oncoprotein interferes with the epithelial cell polarity Par3 proteinSemantic proximity Read ↗

Delta-Like Ligand–Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer PrognosisSemantic proximity Read ↗

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the <i>Drosophila</i> discs large tumor suppressor proteinSemantic proximity Read ↗

Human Papillomavirus E6 interaction with cellular PDZ domain proteins modulates YAP nuclear localizationSemantic proximity Read ↗

Analysis of Multiple HPV E6 PDZ Interactions Defines Type-Specific PDZ Fingerprints That Predict Oncogenic PotentialSemantic proximity Read ↗

E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.