Article
Impaired differentiation of human induced neural stem cells by TOR1A overexpression.
Molecular biology reports - 1 May 2020
Stengel Felix, Vulinovic Franca, Meier Britta, Grütz Karen, Klein Christine, Capetian Philipp
Abstract excerpt
DYT-TOR1A is the most common inherited dystonia caused by a three nucleotide (GAG) deletion (dE) in the TOR1A gene. Death early after birth and cortical anomalies of the full knockout in rodents underscore its developmental importance. We therefore explored the timed effects of TOR1A-wt and TOR1A-dE during differentiation in a human neural in vitro model. We used lentiviral tet-ON expression of TOR1A-wt and -dE...
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