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Longitudinal NK cell kinetics and cytotoxicity in children with neuroblastoma enrolled in a clinical phase II trial

1 Mar 2020

Abstract excerpt

Background Natural killer (NK) cells are one of the main effector populations of immunotherapy with monoclonal antibody and cytokines, used in combination with chemotherapy to treat children with high-risk neuroblastoma on this phase II trial. However, the impact of chemoimmunotherapy on NK cell kinetics, phenotype, and function is understudied. Methods We prospectively examined NK cell properties from 63...

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PMID: 32221013
DOI: 10.1136/jitc-2019-000176

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