Article
Non-active antibiotic and bacteriophage synergism to successfully treat recurrent urinary tract infection caused by extensively drug-resistant Klebsiella pneumoniae.
Emerging microbes & infections - 1 Dec 2020
Bao Juan, Wu Nannan, Zeng Yigang, Chen Liguang, Li Linlin, Yang Lan, Zhang Yiyuan, Guo Mingquan, Li Lisha, Li Jie, Tan Demeng, Cheng Mengjun, Gu Jingmin, Qin Jinghong, Liu Jiazheng, Li Shiru, Pan Guangqiang, Jin Xin, Yao Bangxin, Guo Xiaokui, Zhu Tongyu, Le Shuai
Abstract excerpt
We report a case of a 63-year-old female patient who developed a recurrent urinary tract infection (UTI) with extensively drug-resistant Klebsiella pneumoniae (ERKp). In the initial two rounds of phage therapy, phage resistant mutants developed within days. Although ERKp strains were completely resistant to sulfamethoxazole-trimethoprim, the combination of sulfamethoxazole-trimethoprim with the phage cocktail...
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