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Article

Aortic Aneurysms and Dissections Series: Part II: Dynamic Signaling Responses in Aortic Aneurysms and Dissections.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2020

Shen Ying H, LeMaire Scott A, Webb Nancy R, Cassis Lisa A, Daugherty Alan, Lu Hong S

Abstract excerpt

Aortic structure and function are controlled by the coordinated actions of different aortic cells and the extracellular matrix. Several pathways have been identified that control the aortic wall in a cell-type-specific manner and play diverse roles in various phases of aortic injury, repair, and remodeling. This complexity of signaling in the aortic wall poses challenges to the development of therapeutic...

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PMID: 32208998
DOI: 10.1161/ATVBAHA.120.313804
PMCID: PMC7122036

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