Article
Genetic testing of FUS, HTRA2, and TENM4 genes in Chinese patients with essential tremor.
CNS neuroscience & therapeutics - 1 Aug 2020
Yan Ya-Ping, Xu Cong-Ying, Gu Lu-Yan, Zhang Bo, Shen Ting, Gao Ting, Tian Jun, Pu Jia-Li, Yin Xin-Zhen, Zhang Bao-Rong, Zhao Guo-Hua
Abstract excerpt
INTRODUCTION: Essential tremor (ET) is one of the most prevalent movement disorders. The genetic etiology of ET has not been well defined although a significant proportion (≥50%) are familial cases. Linkage analysis and genome-wide association studies (GWASs) have identified several risk variants. In recent years, whole-exome sequencing of ET has revealed several specific causal variants in FUS (p.Q290X), HTRA2...
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