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Article

MTHFR Ala222Val polymorphism and clinical characteristics confer susceptibility to suicide attempt in chronic patients with schizophrenia.

Scientific reports - 19 Mar 2020

Liu Jia Hong, Zhu Cheng, Zheng Ke, Tang Wei, Gao Li Li, Trihn Tammy H, Emily Wu Hanjing, Chen Da Chun, Hong Xiu Mei, Yang Zhang Xiang

Abstract excerpt

Patients with schizophrenia (SCZ) exhibit higher suicide rates than the general population. However, the molecular mechanism responsible for the high rate of suicidal behavior in SCZ remains poorly understood. MTHFR Ala222Val (C677T; rs 1801133) polymorphism has repeatedly demonstrated to play a pathological role in numerous mental disorders, but none of these studies focused on the susceptibility of suicidal...

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Identifiers

PMID: 32193498
DOI: 10.1038/s41598-020-57411-1
PMCID: PMC7081211

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Source receipt: pubmed, retrieved 7 Sept 2026.

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