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Article

Cutaneous pleomorphic fibromas arising in patients with germline TP53 mutations.

Journal of cutaneous pathology - 1 Aug 2020

Cloutier Jeffrey M, Shalin Sara C, Lindberg Matthew, Gardner Jerad M, Fernandez-Pol Sebastian, Zaba Lisa, Novoa Roberto, Brown Ryanne A

Abstract excerpt

Pleomorphic fibromas are rare benign cutaneous neoplasms associated with deletion/loss of chromosomes 13q and 17p, where RB1 and TP53 are located, respectively. Herein, we report five cases of pleomorphic fibroma arising in patients with germline TP53 mutations, suggesting a potential link with Li-Fraumeni syndrome. All three patients were female and young (mean age 27) with a strong personal and/or family...

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PMID: 32187703
DOI: 10.1111/cup.13686

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