Article
Generation of Variability-Free Reference Proteomes from Pathogenic Organisms for Epitope-Vaccine Design.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020
Sanchez-Trincado Jose L, Reche Pedro A
Abstract excerpt
Many pathogenic organisms have an inherent ability to rapidly evolve into new variants, which enables them to escape previously existing immune responses. Vaccine design strategies should be aimed to counteract such variability, targeting the conserved antigen regions of the pathogen. Sequence variability analysis allows the identification of conserved regions upon multiple sequence alignments of the relevant...
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