Article
The many faces of psoriatic arthritis: their genetic determinism.
Rheumatology (Oxford, England) - 1 Mar 2020
Winchester Robert, FitzGerald Oliver
Abstract excerpt
In this review, we propose a model of PsA as a complex genetically determined autoimmune-mediated disease having a heterogeneous variety of subphenotypes, with each subphenotype under the control of a different susceptibility-associated HLA allele. Since the specific HLA molecules encoded by each susceptibility allele dominantly select a T cell repertoire with the property of recognizing different peptides, we...
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