Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylation Status of the Nanog Promoter Determines the Switch between Cancer Cells and Cancer Stem Cells

23 Jan 2020

Abstract excerpt

Abstract Cancer stem cells (CSCs) are the main cause of tumor development, metastasis, and relapse. CSCs are thus considered promising targets for cancer therapy. However, it is hard to eradicate CSCs due to their inherent plasticity and heterogeneity, and the underlying mechanism of the switch between non‐CSCs and CSCs remains unclear. Here, it is shown that miR‐135a combined with SMYD4 activates Nanog...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Epigenetics and DNA Methylation
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32154082
DOI: 10.1002/advs.201903035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Methylation Status of the Nanog Promoter Determines the Switch between Cancer Cells and Cancer Stem CellsPMID 32154082Read ↗

The oncogenic potential of NANOG: An important cancer induction mediatorSemantic proximity Read ↗

Targeting cancer stem cells: emerging role of Nanog transcription factorSemantic proximity Read ↗

Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44+ cancer stem cells to 5 azacytidine in hepatocellular carcinomaSemantic proximity Read ↗

SALL4 promotes cancer stem-like cell phenotype and radioresistance in oral squamous cell carcinomas via methyltransferase-like 3-mediated m6A modificationSemantic proximity Read ↗

A microRNA-135a/b binding polymorphism in CD133 confers decreased risk and favorable prognosis of lung cancer in Chinese by reducing CD133 expression.Semantic proximity Read ↗

Co-expression of Cancer Stem Cell Markers OCT4 and NANOG Predicts Poor Prognosis in Renal Cell CarcinomasSemantic proximity Read ↗

Downregulation of DNMT3A by miR-708-5p Inhibits Lung Cancer Stem Cell-like Phenotypes through Repressing Wnt/β-catenin Signaling.Semantic proximity Read ↗

Hyaluronan-CD44v3 Interaction with Oct4-Sox2-Nanog Promotes miR-302 Expression Leading to Self-renewal, Clonal Formation, and Cisplatin Resistance in Cancer Stem Cells from Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Epigenetic regulation of CD133/PROM1 expression in glioma stem cells by Sp1/myc and promoter methylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.