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Article

Impact of glioblastoma multiforme associated mutations on the structure and function of MAP/microtubule affinity regulating kinase 4.

Journal of biomolecular structure & dynamics - 1 Mar 2021

Naqvi Ahmad Abu Turab, Jairajpuri Deeba Shamim, Hussain Afzal, Hasan Gulam Mustafa, Alajmi Mohamed F, Hassan Md Imtaiyaz

Abstract excerpt

MAP/Microtubule affinity regulating kinase 4 (MARK4) plays an important role in the regulation of microtubule dynamics by phosphorylation of tau protein. A higher expression of MARK4 is observed in the glioblastoma multiforme (GBM) cell lines. We identified eight synonymous and non-synonymous mutations in the MARK4 gene related to GBM in The Cancer Genome Atlas (TCGA) consortium. Out of these, three...

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Identifiers

PMID: 32141394
DOI: 10.1080/07391102.2020.1738959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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