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Article

A framework using topological pathways for deeper analysis of transcriptome data.

BMC genomics - 5 Mar 2020

Zhao Yue, Piekos Stephanie, Hoang Tham H, Shin Dong-Guk

Abstract excerpt

BACKGROUND: Pathway analysis is one of the later stage data analysis steps essential in interpreting high-throughput gene expression data. We propose a set of algorithms which given gene expression data can recognize which portion of sub-pathways are actively utilized in the biological system being studied. The degree of activation is measured by conditional probability of the input expression data based on the...

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PMID: 32138666
DOI: 10.1186/s12864-019-6155-6
PMCID: PMC7057456

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