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Constraints Shape Cell Function and Morphology by Canalizing the Developmental Path along the Waddington's Landscape.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Apr 2020

Bizzarri Mariano, Giuliani Alessandro, Minini Mirko, Monti Noemi, Cucina Alessandra

Abstract excerpt

Studies performed in absence of gravitational constraint show that a living system is unable to choose between two different phenotypes, thus leading cells to segregate into different, alternative stable states. This finding demonstrates that the genotype does not determine by itself the phenotype but requires additional, physical constraints to finalize cell differentiation. Constraints belong to two classes:...

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PMID: 32105359
DOI: 10.1002/bies.201900108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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