Article
The role of membrane-shaping BAR domain proteins in caveolar invagination: from mechanistic insights to pathophysiological consequences.
Biochemical Society transactions - 28 Feb 2020
Kessels Michael M, Qualmann Britta
Abstract excerpt
The formation of caveolae, bulb-shaped plasma membrane invaginations, requires the coordinated action of distinct lipid-interacting and -shaping proteins. The interdependence of caveolar structure and function has evoked substantial scientific interest given the association of human diseases with caveolar dysfunction. Model systems deficient of core components of caveolae, caveolins or cavins, did not allow for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
