Article
Enhancement of Oxidative Reaction by the Intramolecular Electron Transfer between the Coordinated Redox-Active Metal Ions in SOD1.
The journal of physical chemistry. B - 19 Mar 2020
Ohyama Takumi, Kuroi Kunisato, Wakabayashi Taiyu, Fujimaki Nobuhiro, Nakabayashi Takakazu
Abstract excerpt
The denatured Cu, Zn superoxide dismutase (SOD1) has the pro-oxidant activity that is suggested to be related with the pathogenesis of amyotrophic lateral sclerosis (ALS). We showed from the changes in the coordinated metal ions that the Cu ion in the Cu-binding site is the catalytic site of the pro-oxidant activity, and a redox-active metal ion in the Zn-binding site has the auxiliary function to enhance the...
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