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Article

FMRpolyG accumulates in FMR1 premutation granulosa cells.

Journal of ovarian research - 26 Feb 2020

Friedman-Gohas M, Elizur S E, Dratviman-Storobinsky O, Aizer A, Haas J, Raanani H, Orvieto R, Cohen Y

Abstract excerpt

BACKGROUND: Fragile X premutation (Amplification of CGG number 55-200) is associated with increased risk for fragile X-Associated Premature Ovarian Insufficiency (FXPOI) in females and fragile X-associated tremor/ataxia syndrome (FXTAS) predominantly in males. Recently, it has been shown that CGG repeats trigger repeat associated non-AUG initiated translation (RAN) of a cryptic polyglycine-containing protein,...

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Identifiers

PMID: 32101156
DOI: 10.1186/s13048-020-00623-w
PMCID: PMC7045455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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FMRpolyG accumulates in FMR1 premutation granulosa cells.PMID 32101156Read ↗

Presence of inclusions positive for polyglycine containing protein, FMRpolyG, indicates that repeat-associated non-AUG translation plays a role in fragile X-associated primary ovarian insufficiency.Semantic proximity Read ↗

Evidence for an FMR1 mRNA Gain-Of-Function Toxicity Mechanism in the Pathogenesis of Fragile-X Associated Premature Ovarian InsufficiencySemantic proximity Read ↗

The molecular mechanisms that underlie fragile X-associated premature ovarian insufficiency: is it RNA or protein based?Semantic proximity Read ↗

Understanding decreased fertility in women carriers of the FMR1 premutation: a possible mechanism for Fragile X-Associated Primary Ovarian Insufficiency (FXPOI).Semantic proximity Read ↗

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Insufficiency of 40S ribosomal proteins, RPS26 and RPS25, negatively affects biosynthesis of polyglycine-containing proteins in fragile-X associated conditionsSemantic proximity Read ↗

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Elevated Levels of FMR1 mRNA in Granulosa Cells Are Associated with Low Ovarian Reserve in FMR1 Premutation CarriersSemantic proximity Read ↗

Long CGG-repeat tracts are toxic to human cells: implications for carriers of Fragile X premutation alleles.Semantic proximity Read ↗

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