Article
Presence of inclusions positive for polyglycine containing protein, FMRpolyG, indicates that repeat-associated non-AUG translation plays a role in fragile X-associated primary ovarian insufficiency.
Human reproduction (Oxford, England) - 1 Jan 2016
Buijsen R A M, Visser J A, Kramer P, Severijnen E A W F M, Gearing M, Charlet-Berguerand N, Sherman S L, Berman R F, Willemsen R, Hukema R K
Abstract excerpt
STUDY QUESTION: Does repeat-associated non-AUG (RAN) translation play a role in fragile X-associated primary ovarian insufficiency (FXPOI), leading to the presence of polyglycine containing protein (FMRpolyG)-positive inclusions in ovarian tissue? SUMMARY ANSWER: Ovaries of a woman with FXPOI and of an Fmr1 premutation (PM) mouse model (exCGG-KI) contain intranuclear inclusions that stain positive for both...
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