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Article

FOXO4 expression associates with glioblastoma development and FOXO4 expression inhibits cell malignant phenotypes in vitro and in vivo.

Life sciences - 15 Apr 2020

Qi Min, Sun Le-An, Jiang Xiao-Chun, Han Yan-Ling, Wang Lin, Niu Wen-Hao, Fei Mao-Xing, Zhaba Wang-Dui, Zheng Lan-Rong, Zhou Meng-Liang

Abstract excerpt

BACKGROUND AND AIM: Forkhead box protein O4 (FOXO4) is a transcription factor, and aberrant FOXO4 expression is associated with development of various human cancers. This study explored the role of FOXO4 in glioma in vitro and in vivo. METHODS: FOXO4 expression was first assessed in normal brain tissues, low-grade glioma, glioblastoma multiforme (GBM), normal human astrocytes (HA), and GBM cell lines, while...

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Identifiers

PMID: 32070707
DOI: 10.1016/j.lfs.2020.117436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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