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Genomic epidemiology of Vibrio cholerae reveals the regional and global spread of two epidemic non-toxigenic lineages.

PLoS neglected tropical diseases - 1 Feb 2020

Wang Haoqiu, Yang Chao, Sun Zhou, Zheng Wei, Zhang Wei, Yu Hua, Wu Yarong, Didelot Xavier, Yang Ruifu, Pan Jingcao, Cui Yujun

Abstract excerpt

Non-toxigenic Vibrio cholerae isolates have been found associated with diarrheal disease globally, however, the global picture of non-toxigenic infections is largely unknown. Among non-toxigenic V. cholerae, ctxAB negative, tcpA positive (CNTP) isolates have the highest risk of disease. From 2001 to 2012, 71 infectious diarrhea cases were reported in Hangzhou, China, caused by CNTP serogroup O1 isolates. We...

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PMID: 32069325
DOI: 10.1371/journal.pntd.0008046
PMCID: PMC7048298

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