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Article

Reversible EMT and MET mediate amnion remodeling during pregnancy and labor

11 Feb 2020

Abstract excerpt

The amnion is remodeled during pregnancy to protect the growing fetus it contains, and it is particularly dynamic just before and during labor. By combining ultrastructural, immunohistochemical, and Western blotting analyses, we found that human and mouse amnion membranes during labor were subject to epithelial-to-mesenchymal transition (EMT), mediated, in part, by the p38 mitogen-activated protein kinase (MAPK)...

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PMID: 32047115
DOI: 10.1126/scisignal.aay1486

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