Single cell transcriptomic analysis of human amnion identifies cell-specific signatures associated with membrane rupture and parturition

Abstract excerpt

BACKGROUND: The human amnion is an intrauterine tissue which is involved in the initiation of parturition. In-depth understanding of gene expression signatures of individual cell types in the amnion with respect to membrane rupture at parturition may help identify crucial initiators of parturition for the development of specific strategies to prevent preterm birth, a leading cause of perinatal mortality. RESULTS:...

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