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Article

Glutathione catabolism by Treponema denticola impacts its pathogenic potential.

Anaerobe - 1 Apr 2020

Chu Lianrui, Wu Yimin, Xu Xiaoping, Phillips Linda, Kolodrubetz David

Abstract excerpt

Treponema denticola is a spirochete that is etiologic for periodontal diseases. This bacterium is one of two periodontal pathogens that have been shown to have a complete three step enzymatic pathway (GTSP) that catabolizes glutathione to H2S. This pathway may contribute to the tissue pathology seen in periodontitis since diseased periodontal pockets have lower glutathione levels than healthy sites with a...

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Identifiers

PMID: 32044394
DOI: 10.1016/j.anaerobe.2020.102170
PMCID: PMC7153967

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