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Article

Screening of the glucocerebrosidase (GBA) gene in South Africans of African ancestry with Parkinson's disease.

Neurobiology of aging - 1 Apr 2020

Mahungu Amokelani C, Anderson David G, Rossouw Anastasia C, van Coller Riaan, Carr Jonathan A, Ross Owen A, Bardien Soraya

Abstract excerpt

Sequence variants in glucocerebrosidase (GBA) are a major genetic risk factor for Parkinson's disease (PD), and display ethnic-dependent frequencies, for example, variants such as p.N370S and 84insGG are common in Ashkenazi Jewish patients. Notably, there are limited studies on black patients from the African continent; hence, we conducted a study on 30 South African black PD patients. All 11 exons of GBA were...

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Identifiers

PMID: 32035846
DOI: 10.1016/j.neurobiolaging.2019.12.011
PMCID: PMC7085451

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