Myoviridae phage PDX kills enteroaggregative Escherichia coli without human microbiome dysbiosis

Abstract excerpt

Introduction. Bacteriophage therapy can be developed to target emerging diarrhoeal pathogens, but doing so in the absence of microbiome disruption, which occurs with antibiotic treatment, has not been established. Aim. Identify a therapeutic bacteriophage that kills diarrhoeagenic enteroaggregative Escherichia coli (EAEC) while leaving the human microbiome intact. Methodology. Phages from wastewater in Portland,...

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