Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer.

doi:10.1126/sciadv.aax0021

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Article

Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer.

Science advances - 1 Jan 2020

Yan Kezhi, Rousseau Justine, Machol Keren, Cross Laura A, Agre Katherine E, Gibson Cynthia Forster, Goverde Anne, Engleman Kendra L, Verdin Hannah, De Baere Elfride, Potocki Lorraine, Zhou Dihong, Cadieux-Dion Maxime, Bellus Gary A, Wagner Monisa D, Hale Rebecca J, Esber Natacha, Riley Alan F, Solomon Benjamin D, Cho Megan T, McWalter Kirsty, Eyal Roy, Hainlen Meagan K, Mendelsohn Bryce A, Porter Hillary M, Lanpher Brendan C, Lewis Andrea M, Savatt Juliann, Thiffault Isabelle, Callewaert Bert, Campeau Philippe M, Yang Xiang-Jiao

Abstract excerpt

Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3 at lysine 23 (H3K23). We report that these complexes also catalyze H3K23 propionylation in vitro and in vivo. Immunofluorescence microscopy and ATAC-See revealed the association of this modification with active chromatin. Brpf1 deletion...

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PMID: 32010779
DOI: 10.1126/sciadv.aax0021
PMCID: PMC6976298

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