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Article

Induction of apoptosis increases sensitivity to detect cancer mutations in plasma.

European journal of cancer (Oxford, England : 1990) - 1 Mar 2020

Marques Joana F, Junqueira-Neto Susana, Pinheiro Jorge, Machado José C, Costa José L

Abstract excerpt

BACKGROUND: The study of cell-free DNA (cfDNA), namely the fraction derived from tumors (ctDNA), is a clinically relevant noninvasive biomarker for cancer management. However, the intrinsic low abundance of ctDNA in plasma limits its implementation in the clinic. AIM OF THE STUDY: In this study, the objective was to demonstrate that induction of apoptosis-the major source of ctDNA-increases ctDNA concentration,...

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Identifiers

PMID: 32007713
DOI: 10.1016/j.ejca.2019.12.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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