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Article

Performance comparison of next generation sequencing analysis pipelines for HIV-1 drug resistance testing.

Scientific reports - 31 Jan 2020

Lee Emma R, Parkin Neil, Jennings Cheryl, Brumme Chanson J, Enns Eric, Casadellà Maria, Howison Mark, Coetzer Mia, Avila-Rios Santiago, Capina Rupert, Marinier Eric, Van Domselaar Gary, Noguera-Julian Marc, Kirkby Don, Knaggs Jeff, Harrigan Richard, Quiñones-Mateu Miguel, Paredes Roger, Kantor Rami, Sandstrom Paul, Ji Hezhao

Abstract excerpt

Next generation sequencing (NGS) is a trending new standard for genotypic HIV-1 drug resistance (HIVDR) testing. Many NGS HIVDR data analysis pipelines have been independently developed, each with variable outputs and data management protocols. Standardization of such analytical methods and comparison of available pipelines are lacking, yet may impact subsequent HIVDR interpretation and other downstream...

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Identifiers

PMID: 32005884
DOI: 10.1038/s41598-020-58544-z
PMCID: PMC6994664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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