Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Papillomavirus 58 E7 T20I/G63S Variant Isolated from an East Asian Population Possesses High Oncogenicity.

Journal of virology - 31 Mar 2020

Boon Siaw Shi, Xia Chichao, Lim Jin Yan, Chen Zigui, Law Priscilla T Y, Yeung Apple C M, Thomas Miranda, Banks Lawrence, Chan Paul K S

Abstract excerpt

Human papillomavirus (HPV) type 58 is the third most commonly detected HPV type in cervical cancer among Eastern Asians. Our previous international epidemiological studies revealed that HPV58 carrying an E7 natural variant, T20I/G63S (designated V1), was associated with a higher risk of cervical cancer. We recently showed that V1 possesses a greater ability to immortalize and transform primary cells, as well as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Mice, Nude

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins, Viral

Share to Papillomaviridae

Share to Papillomavirus Infections

Share to Papillomavirus Vaccines

Share to Uterine Cervical Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 31996427
DOI: 10.1128/JVI.00090-20
PMCID: PMC7108839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Papillomavirus 58 E7 T20I/G63S Variant Isolated from an East Asian Population Possesses High Oncogenicity.PMID 31996427Read ↗

The Asian-American E6 variant protein of human papillomavirus 16 alone is sufficient to promote immortalization, transformation, and migration of primary human foreskin keratinocytes.Semantic proximity Read ↗

Ancient Evolution and Dispersion of Human Papillomavirus 58 Variants.Semantic proximity Read ↗

E6/E7 Functional Differences among Two Natural Human Papillomavirus 18 Variants in Human Keratinocytes.Semantic proximity Read ↗

Human papillomavirus type 58: the unique role in cervical cancers in East AsiaSemantic proximity Read ↗

The Asian-American variant of human papillomavirus type 16 exhibits higher activation of MAPK and PI3K/AKT signaling pathways, transformation, migration and invasion of primary human keratinocytes.Semantic proximity Read ↗

Transforming Properties of E6/E7 Oncogenes from Beta-2 HPV80 in Primary Human FibroblastsSemantic proximity Read ↗

Human Papillomavirus Type 16 E6 Amino Acid 83 Variants Enhance E6-Mediated MAPK Signaling and Differentially Regulate Tumorigenesis by Notch Signaling and Oncogenic RasSemantic proximity Read ↗

Oncogenic potential diverge among human papillomavirus type 16 natural variants.Semantic proximity Read ↗

The immortalizing and transforming ability of two common human papillomavirus 16 E6 variants with different prevalences in cervical cancerSemantic proximity Read ↗

E7 Oncogene HPV 58 Variants Detected in Northeast Brazil: Genetic and Functional AnalysisSemantic proximity Read ↗

MEK/ERK signaling is a critical regulator of high-risk human papillomavirus oncogene expression revealing therapeutic targets for HPV-induced tumorsSemantic proximity Read ↗

Transforming Properties of Beta-3 Human Papillomavirus E6 and E7 ProteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.