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Article

A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy.

Human molecular genetics - 8 May 2020

Wang Yanshu, Smallwood Philip M, Williams John, Nathans Jeremy

Abstract excerpt

During mitosis, Kif11, a kinesin motor protein, promotes bipolar spindle formation and chromosome movement, and during interphase, Kif11 mediates diverse trafficking processes in the cytoplasm. In humans, inactivating mutations in KIF11 are associated with (1) retinal hypovascularization with or without microcephaly and (2) multi-organ syndromes characterized by variable combinations of lymphedema, chorioretinal...

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Identifiers

PMID: 31993640
DOI: 10.1093/hmg/ddaa018
PMCID: PMC7206855

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