Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy.

Nature communications - 20 Nov 2019

Park Hongryeol, Yamamoto Hiroyuki, Mohn Lucas, Ambühl Lea, Kanai Kenichi, Schmidt Inga, Kim Kee-Pyo, Fraccaroli Alessia, Feil Silke, Junge Harald J, Montanez Eloi, Berger Wolfgang, Adams Ralf H

Abstract excerpt

Familial exudative vitreoretinopathy (FEVR) is a human disease characterized by defective retinal angiogenesis and associated complications that can result in vision loss. Defective Wnt/β-catenin signaling is an established cause of FEVR, whereas other molecular alterations contributing to the disease remain insufficiently understood. Here, we show that integrin-linked kinase (ILK), a mediator of cell-matrix...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endothelial Cells
Share to Familial Exudative Vitreoretinopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human Umbilical Vein Endothelial Cells

Share to Microfilament Proteins

Share to Neovascularization, Physiologic

Share to Protein Serine-Threonine Kinases

Share to Retinal Vessels

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 31748531
DOI: 10.1038/s41467-019-13220-3
PMCID: PMC6868140

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy.PMID 31748531Read ↗

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy.Semantic proximity Read ↗

Retinal Features of Family Members With Familial Exudative Vitreoretinopathy Caused By Mutations in KIF11 Gene.Semantic proximity Read ↗

Phenotypic overlap between familial exudative vitreoretinopathy and microcephaly, lymphedema, and chorioretinal dysplasia caused by KIF11 mutations.Semantic proximity Read ↗

KIF11 mutations are a common cause of autosomal dominant familial exudative vitreoretinopathy.Semantic proximity Read ↗

Modeling ZNF408-Associated FEVR in Zebrafish Results in Abnormal Retinal VasculatureSemantic proximity Read ↗

Defective CAPSL function causes impaired retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathySemantic proximity Read ↗

A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy.Semantic proximity Read ↗

Whole-Exome Sequencing Identified DLG1 as a Candidate Gene for Familial Exudative Vitreoretinopathy.Semantic proximity Read ↗

Catenin α 1 mutations cause familial exudative vitreoretinopathy by overactivating Norrin/β-catenin signaling.Semantic proximity Read ↗

ZNF408 is mutated in familial exudative vitreoretinopathy and is crucial for the development of zebrafish retinal vasculature.Semantic proximity Read ↗

Identification of novel KIF11 mutations in patients with familial exudative vitreoretinopathy and a phenotypic analysis.Semantic proximity Read ↗

A new locus for autosomal dominant familial exudative vitreoretinopathy maps to chromosome 11p12-13.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.