Article
A misprocessed form of Apolipoprotein A-I is specifically associated with recurrent Focal Segmental Glomerulosclerosis.
Scientific reports - 24 Jan 2020
Jacobs-Cachá Conxita, Puig-Gay Natàlia, Helm Dominic, Rettel Mandy, Sellarès Joana, Meseguer Anna, Savitski Mikhail M, Moreso Francesc J, Soler Maria José, Seron Daniel, Lopez-Hellin Joan
Abstract excerpt
Apolipoprotein A-Ib (ApoA-Ib) is a high molecular weight form of Apolipoprotein A-I (ApoA-I) found specifically in the urine of kidney-transplanted patients with recurrent idiopathic focal segmental glomerulosclerosis (FSGS). To determine the nature of the modification present in ApoA-Ib, we sequenced the whole APOA1 gene in ApoA-Ib positive and negative patients, and we also studied the protein primary structure...
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