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Article

Lysine acetylation of the housekeeping sigma factor enhances the activity of the RNA polymerase holoenzyme.

Nucleic acids research - 18 Mar 2020

Kim Ji-Eun, Choi Joon-Sun, Kim Jong-Seo, Cho You-Hee, Roe Jung-Hye

Abstract excerpt

Protein lysine acetylation, one of the most abundant post-translational modifications in eukaryotes, occurs in prokaryotes as well. Despite the evidence of lysine acetylation in bacterial RNA polymerases (RNAPs), its function remains unknown. We found that the housekeeping sigma factor (HrdB) was acetylated throughout the growth of an actinobacterium, Streptomyces venezuelae, and the acetylated HrdB was enriched...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31970401
DOI: 10.1093/nar/gkaa011
PMCID: PMC7049703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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