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Article

Multi-lineage Lung Regeneration by Stem Cell Transplantation across Major Genetic Barriers

1 Jan 2020

Abstract excerpt

Induction of lung regeneration by transplantation of lung progenitor cells is a critical preclinical challenge. Recently, we demonstrated that robust lung regeneration can be achieved if the endogenous stem cell niches in the recipient's lung are vacated by sub-lethal pre-conditioning. However, overcoming MHC barriers is an additional requirement for clinical application of this attractive approach. We...

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PMID: 31968255
DOI: 10.1016/j.celrep.2019.12.058

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