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Article

Fecal dysbiosis in infants with cystic fibrosis is associated with early linear growth failure.

Nature medicine - 1 Feb 2020

Hayden Hillary S, Eng Alexander, Pope Christopher E, Brittnacher Mitchell J, Vo Anh T, Weiss Eli J, Hager Kyle R, Martin Bryan D, Leung Daniel H, Heltshe Sonya L, Borenstein Elhanan, Miller Samuel I, Hoffman Lucas R

Abstract excerpt

Most infants with cystic fibrosis (CF) have pancreatic exocrine insufficiency that results in nutrient malabsorption and requires oral pancreatic enzyme replacement. Newborn screening for CF has enabled earlier diagnosis, nutritional intervention and enzyme replacement for these infants, allowing most infants with CF to achieve their weight goals by 12 months of age1. Nevertheless, most infants with CF continue...

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Identifiers

PMID: 31959989
DOI: 10.1038/s41591-019-0714-x
PMCID: PMC7018602

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