Article
Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes.
Nature microbiology - 1 Feb 2020
Wang Ya-Ting, Zaitsev Konstantin, Lu Qun, Li Shan, Schaiff W Timothy, Kim Ki-Wook, Droit Lindsay, Wilen Craig B, Desai Chandni, Balce Dale R, Orchard Robert C, Orvedahl Anthony, Park Sunmin, Kreamalmeyer Darren, Handley Scott A, Pfeifer John D, Baldridge Megan T, Artyomov Maxim N, Stallings Christina L, Virgin Herbert W
Abstract excerpt
Innate and adaptive immune responses that prime myeloid cells, such as macrophages, protect against pathogens1,2. However, if left uncontrolled, these responses may lead to detrimental inflammation3. Macrophages, particularly those resident in tissues, must therefore remain quiescent between infections despite chronic stimulation by commensal microorganisms. The genes required for quiescence of tissue-resident...
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